Abstract P-217

Dmd060046 217..226

5-[(2-Chloro-6-fluorophenyl)acetylamino]-3-(4-fluorophenyl)-4(4-pyrimidinyl)isoxazole (AKP-001) is a potent p38 mitogen-activated protein kinase inhibitor that is being developed to specifically target the intestines for the treatment of inflammatory bowel disease. According to the ante-drug concept, AKP-001 was designed to be metabolized to inactive forms via the first-pass metabolism to avoid...

COS 217, Spring 2005

212-217 Riehmann

been rising, it represents only 20% of method use among 15–44-year-old women.7 In addition, the widespread availability of modern, efficient contraceptives—sterilization, the pill, IUD, implant and injectable—contributes to low rates of condom use. However, while these methods are more effective than barrier methods at preventing pregnancy, do not reduce sensitivity or pleasure during intercour...

Npgrj_nmeth_720 209..217

Nearly every major process in a cell is carried out by assemblies of multiple dynamically interacting protein molecules. To study multi-protein interactions within such molecular machineries, we have developed a fluorescence microscopy method called three-chromophore fluorescence resonance energy transfer (3-FRET). This method allows analysis of three mutually dependent energy transfer processe...

Nen20729 201..217

Major changes in arterial pressure, autonomic, and respiratory activity occur in response to hypoxia. We analyzed structural damage and increased vascular permeability in the ventrolateral medulla and nucleus tractus solitarius, which control autonomic, respiratory, and cardiovascular functions in adult Wistar rats subjected to 2 hours of hypoxia (7% oxygen + 93% nitrogen) for up to 14 days aft...